What kind of traditional Chinese medicine is cantharis?
Cantharidin is a traditional Chinese medicinal material that has become a hot topic again in recent years due to its unique pharmacological effects and potential application value. This article will combine the hot content of the entire Internet in the past 10 days to introduce in detail the source, efficacy, usage and precautions of cantharis, and present relevant research progress in structured data.
1. The origin and basic introduction of cantharis

Cantharidin is the dried body of the southern large Cantharis or the yellow-black small Cantharis of the family Colicinaceae. It is mainly produced in Henan, Guangxi, Jiangsu and other places in China. Its nature and flavor are pungent and hot, and it is highly poisonous. It belongs to the liver, stomach, and kidney meridian. It is traditionally used to break blood and remove blood stasis, dissipate stagnation and eliminate diseases, and attack toxins and ulcers.
| Classification | content |
|---|---|
| Chinese name | Cantharides |
| Latin name | Mylabris phalerata/Mylabris cichorii |
| Medicinal parts | Whole dry adult worm |
| Main ingredients | Cantharidin |
| toxicity | Extremely poisonous (needs to be concocted before use) |
2. Efficacy and clinical application of cantharis
Recent studies have shown that the anti-tumor effect of cantharidin has become the focus of attention in the medical community. The following are its core functions and hot applications:
| Efficacy classification | Specific applications | Research Progress (2024) |
|---|---|---|
| Anti-tumor | Adjuvant treatment for liver cancer and gastric cancer | The Shanghai Jiao Tong University team discovered that cantharidin derivatives can inhibit the PD-1/PD-L1 pathway |
| dermatology | Psoriasis, vitiligo | "Chinese Journal of Traditional Chinese Medicine" reports that the new formula of cantharides tincture has a 40% improvement in efficacy |
| rheumatism immunity | rheumatoid arthritis | AI selects the best compatibility ratio of cantharidin and tripterygium wilfordii |
3. Precautions for use
The recent "cantharidin health wine poisoning incident" that has been hotly discussed on the Internet highlights the importance of standardized medication:
1.Disabled conditions: Absolutely prohibited for pregnant women and the infirm; use with caution in those with heart and kidney dysfunction.
2.poisoning symptoms: Burning pain in the mouth, hematuria, shock (need immediate gastric lavage and atropine injection)
3.Latest regulations: In 2024, the State Food and Drug Administration will include Cantharidin in the key regulatory catalog of 28 toxic Chinese medicinal materials.
4. Market dynamics and scientific research results
| field | Hot content | Data source |
|---|---|---|
| price trend | The purchase price of wild cantharis rose to 2,800 yuan/kg (+15% year-on-year) | Traditional Chinese Medicine World Network |
| Scientific research results | Cantharidin nanodrug delivery system completes animal experiments | "Nature" sub-journal |
| network attention | Douyin’s #cantharides topic has been played 120 million times | Cicada mother data |
5. Balance between traditional and modern applications
The recent controversy among experts focuses on two points:
1.Inheritance of traditional cooking techniques: Jiangsu’s intangible cultural heritage technique of “fried cantharides with rice” is at risk of being lost.
2.modern research ethics: Gene-edited cantharidin synthesis pathway triggers biosafety discussion
The latest "Clinical Application Guidelines for Cantharidin (2024 Edition)" released by the China Academy of Chinese Medical Sciences recommends that clinical use should follow the principle of "starting with a small dose and stopping when the disease is severe", and the concentration of external preparations should not exceed 0.5%.
Conclusion:As a representative of "strong poisons", cantharidin's research and application embody the unique wisdom of traditional Chinese medicine of "fighting poison with poison". With the intervention of modern technology, this ancient medicinal material is taking on new vitality, but we must be wary of the risk of abuse brought about by commercial hype. Consumers should use related products under the guidance of professional physicians.
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